Pomolic acid inhibits proliferation of human lung carcinoma cells via induction of apoptosis and suppression of cell migration and invasion
نویسندگان
چکیده
Purpose: To investigate the anti-proliferative effect of pomolic acid on lung cancer cells (A549), and theunderlying mechanism.Methods: The viability acid-treated A549 was determined by MTT colony formation assays. Cell monitored with acridine orange/ethidium bromide (AO/EB) staining. Protein expressions Bax Bcl-2 were assayed western blotting.Results: Pomolic suppressed growth cells, an half-maximal inhibitory concentration (IC50) 10 μM (p < 0.05). However, IC50 for normal BEAS-2B 80 μM. also decreased cells. At 20 μM, percentage colonies to 14 % control. dose-dependent cytotoxicity against mediated via induction apoptosis oxidative stress. treatment enhanced expression in Moreover, inhibited migration invasion a manner 0.05).Conclusion: These results indicate potent anticancer human Thus, has promising potential as lead molecule development chemotherapy.
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ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2022
ISSN: ['1596-5996', '1596-9827']
DOI: https://doi.org/10.4314/tjpr.v21i6.10